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Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 3,   Pages 433-440 doi: 10.1007/s11783-013-0594-0

Abstract: Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrinedisruption, and an ethoxy resorufin-O-deethylase (EROD) assay using H4IIE cells for aryl hydrocarbon

Keywords： sewage sludge     in vitro bioassay     endocrine disruption     dioxin-like effect    

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Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1525-8

Abstract:

• Effect of gastric fluid on EDCs adsorption-desorption to microplastics was evaluated.

Keywords： Microplastics     Gastric fluid     Endocrine-disrupting chemicals     Adsorption     Desorption    

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Two-stage stochastic programming with robust constraints for the logistics network post-disruption response

Frontiers of Engineering Management   Pages 67-81 doi: 10.1007/s42524-022-0240-2

Abstract: To address the LN post-disruption response strategy optimization problem, this study proposes a novel

Keywords： logistics network design     post-disruption response strategy     two-stage stochastic programming     conditional    

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Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1805-6

Abstract:

● Urethane functionalities created on PES membranes via electron beam irradiation.

Keywords： Surface functionalization     Electron beam irradiation     Microfiltration     Endocrine disrupting chemicals    

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Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 475-481 doi: 10.1007/s11783-014-0640-6

Abstract: Endocrine disrupting compounds (EDCs), pharmaceuticals and personal care products (PPCPs) have attracted

Keywords： endocrine disrupting compounds (EDCs)     pharmaceuticals and personal care products (PPCPs)     fish     bisphenol    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrine

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 4, doi: 10.1007/s11783-021-1474-7

Abstract:

• PA layer properties tune the primary nanochannels in MIL-101(Cr) TFN NF membranes.

Keywords： organic framework     Thin-film nanocomposite membrane     Primary selective nanochannels     Nanofiltration     Endocrine    

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Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 18-26 doi: 10.1007/s11783-013-0573-5

Abstract: purpose of this study was to give a worldwide overview of the concentrations of typical estrogenic endocrine

Keywords： estrogenic endocrine disrupting chemicals     concentration distribution     sewage plant    

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In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 69-78 doi: 10.1007/s11783-013-0502-7

Abstract: Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine

Keywords： waste water     in vitro     recombinant yeast assay     ethoxyresorufin-O-deethylase (EROD)     receptor     endocrine    

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Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 350-356 doi: 10.1007/s11783-007-0060-y

Abstract: The ozone oxidation of endocrine disruptor bisphenol A in drinking water was investigated.

Keywords： BPA     scanning     reactor     process     O-HO    

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Modeling of the resilient supply chain system from a perspective of production design changes

Frontiers of Engineering Management   Pages 96-106 doi: 10.1007/s42524-022-0235-z

Abstract: To overcome the impact of insufficient raw material supply on the supply chain in mass disruption scenarios

Keywords： resilient supply chain     supply chain disruption     domain modeling     product design changes    

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Enhanced production of

Shen Huang,Xudong Feng,Chun Li

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 501-510 doi: 10.1007/s11705-015-1544-0

Abstract: -Glucuronidase from Li-3 (PGUS) can efficiently hydrolyze glycyrrhizin into the more valuable glycyrrhetic acid monoglucuronide. However, a low productivity of PGUS and the lack of an effective separation strategy have significantly limited its industrial applications. Therefore, the production of PGUS has been improved by optimizing both the fermentation and purification strategies. A two-stage fermentation strategy was developed where PGUS was first grown with glucose and then PGUS was produced in the presence of glycyrrhizin as an inducer. By using this strategy, the biomass was increased 1.5 times and the PGUS activity increased 5.4 times compared to that when glycyrrhizin was used as the sole carbon source. The amount of PGUS produced was increased another 16.6% when the fermentation was expanded to a 15-L fermenter. An effective protocol was also established to purify the PGUS using a sequential combination of hydrophobic, strong anion-exchange and gel filtration chromatography. This protocol had a recovery yield of 6% and gave PGUS that was 39 times purer than the crude PGUS. The purified PGUS had a specific activity of 350 U·mg .

Keywords： β-glucuronidase     glycyrrhetic acid monoglucuronide     cell disruption     purification     chromatography    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: acquiring affinity for transmembrane α-Klotho (KL) or β-KL as a coreceptor, thereby adapting to an endocrinecell proliferation and growth sufficiently necessitate a new unified and specific term for these three endocrineThus, the term “FGF Metabolic Axis,” which distinguishes the unique pathways and functions of endocrine

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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Modeling the aqueous reaction kinetics of estriol with ferrate

Cong LI, Naiyun GAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 39-45 doi: 10.1007/s11705-009-0098-4

Abstract: In this study the aqueous oxidation kinetics of estriol (E3) by potassium ferrate (K FeO ), a chemical for its strong oxidizing power and for producing a coagulant from its reduced state (i.e. Fe(III)), was evaluated in the range of pH 8-12 with different molar ratios of the reactants. As the degree of Fe(VI) protonation varies with the solution pH, it was found that a first order model was not suitable to describe the oxidation reaction. This paper describes a theoretical representation that closely models the reaction kinetics of E3 and ferrate. From this modeling, the reaction rates of HFe and Fe with E3 have been determined. The results show that the reactivity of HFe with dissociated and undissociated E3 is greater than that of Fe , and that E3 is more reactive in its dissociated state.

Keywords： ferrate     estriol     endocrine disruptor     kinetics     oxidation    

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Title Author Date Type Operation

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

Journal Article

Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

Journal Article

Two-stage stochastic programming with robust constraints for the logistics network post-disruption response

Journal Article

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

Journal Article

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrine

Journal Article

Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

Journal Article

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

Journal Article

Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

Journal Article

Modeling of the resilient supply chain system from a perspective of production design changes

Journal Article

Enhanced production of

Shen Huang,Xudong Feng,Chun Li

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

The FGF metabolic axis

Xiaokun Li

Journal Article

Modeling the aqueous reaction kinetics of estriol with ferrate

Cong LI, Naiyun GAO

Journal Article